The Electro Nerve Regeneration (ENR) Therapy offered at Relievus safely delivers a sophisticated electric signal to the body’s deep tissue via adhesive electrode patches in accordance with your treatment plan, your provider will either place the electrodes anatomically to impact specific affected nerves or place them closer to a central nerve branch to treat a wider area of the body. The effectiveness of Electro Nerve Regeneration (ENR) Therapy is due to sophistication the electronic signal used. The signal has a wide frequency range that sweeps from 40,000 HZ-400HZ and the signals wave form is similar to the electronic pattern generated by the body itself. The combination of wide frequency range and electronic capability with the body allows the signal to reach more types of cells and nerve fibers and produce greater benefit in each. Nerves are 60% more conductive than any other tissue or cells. As all energy travels the path of least resistance, this means the energy of the applied electronic signal is drawn more directly to the nerve cells, where it does the most good. The Electro Nerve Regeneration (ENR) Therapy treatment promotes change at the cellular level, increasing cellular metabolism, normalizing pH, removing excess fluids and waste products that cause swelling and pain—all of which encourage healing. The body is essentially healing itself, making this a self-healing treatment. The end result is a decrease in neuropathy symptoms and elimination or reduction of related pain.
Peripheral nerves have the ability to regenerate and heal! The Nerve Pain Center at Relievus helps you to treat and repair your nerves.
Medical Researchers are still exploring the details of how nerve cells function and regenerate. They are still investigating how illness and injury damages nerves and result in ongoing pain and numbness and are still learning how to best restore nerve health and function. Although our medical knowledge continues to grow, the truth is that many existing neuropathy treatments are ineffective, have short term results or rely on narcotics that can have potentially severe side effects. Electro Nerve Regeneration (ENR) Therapy is an electronic therapy that has dramatically changed these types of neuropathy treatment outcomes for thousands of patients across the country. After the Electro Nerve Regeneration (ENR) Therapy, more than 4 out of 5 patients (87%) have experienced complete resolution of their neuropathy symptoms or have experienced such a significant reduction in their symptoms that they reported an improved quality of life. The Electro Nerve Regeneration (ENR) Therapy works equally well for men and women, regardless of age. It also works well regardless of the duration of existing symptoms; both patients recently diagnosed with neuropathy and those who have suffered with chronic nerve conditions for 20 to 30 years or more, have experienced restorative results with the Electro Nerve Regeneration (ENR) Therapy. In short, this means the odds are very good that our electrotherapy treatment it will benefit you. However, as with all medical treatments, results vary depending on your age, condition, treatment compliance, genetics, diagnosis and other factors. To find out if Electro Nerve Regeneration (ENR) Therapy can help resolve your symptoms and improve your quality of life, request an evaluation from our provider at Relievus.
No. As Electro Nerve Regeneration (ENR) Therapy is non-invasive and non-surgical, the treatments are safely done in the office. ENR Therapy is the easiest way to get treated for nerve pain.
Electro Nerve Regeneration (ENR) Therapy’s treatment is not recommended for patients who are pregnant, who have pacemakers, or who have spinal cord stimulators.
The Electro Nerve Regeneration (ENR) Therapy has been successful for thousands of patients across the country. In more than 4 out of 5 patients. (87%), treatment resolved or significantly reeducated neuropathy symptoms such as; Pain, cramping, numbness, hypersensitivity, burning and tingling. Results have been confirmed by nerve conduction studies and nerve fiber density tests. We have the best electrotherapy in NJ.
Physicians, Physician Assistants, Nurse Practitioners and Medical Assistants can provide Electro Nerve Regeneration (ENR) Therapy at Relievus.
The Electro Nerve Regeneration (ENR) Therapy is actually a treatment course that takes place over multiple sessions typically spanning a 4 to 6-week period. The length of each individual treatment session is about 40 minutes. The patients are scheduled for 2-3 treatments per week during the treatment course.
Depending on the individual patient factors, including the severity of symptoms, the total number of treatments can vary from a low of 8 to 12 sessions or may vary to as many as 16 to 24. The actual number will depend on the patient response treatments.
Patients typically feel improvement as a return sensation and coordination and a reduction in pain. It is important to note that in the initial stages – as damaged nerves begin to heal- the return of sensation can sometimes be experienced as pain of varying degrees. This is a normal part of the restorative process and is usually limited in duration, disappearing as treatment progresses and sensation more fully recovers.
In addition to your personal perception of changes in your symptoms, clinicians do a number of things to objectively evaluate your progress. Using a pain assessment scale, they will chart your feedback about changes in pain and other symptoms for comparison over time. In addition, they will assess improvement with physical exams. This documentation makes it easy for you to see the progress over the course of treatment.

Are there clinical studies supporting ENR?


Electro analgesic medical treatment (also known as Electronic Signal Treatment, or EST) involves the use of computer-modulated electronic signals to imitate, exhaust or block the function of somatic or sympathetic nerve fibers. (EST devices) utilize communications-level technology to produce and deliver high-frequency signal energy in a continually varying sequential and random pattern via specialty electrodes. These electrodes (of specific size, shape and anatomical placement) can be effectively used to obtain pharmaceutical effects. The use of specific harmonic frequencies effectively increases the initiation of tissue resonance phenomenon in the microstructure and macromolecular range. Some well-known and well documented mechanisms of action employed by this harmonic resonance include the imitation of hormone/ligand effects, activation of cellular regeneration and the facilitation of enzymatic metabolic processes.

Without piercing the skin, physicians can now administer effective nerve pain treatments to reduce the hyper-irritated state of the nerves. This is accomplished by placing specific surface electrodes on the skin and introducing very specific bioelectric signal impulses to produce an electro analgesic nerve axon blocking procedure. The strength of this targeted procedural treatment field reduces the ability of the affected nerves to transmit pain signals and, at the same time, promotes healing by means of the depo- larization effects on the nerve cells. It is the authors’ belief that this technology has the potential to modify how interventional pain management is practiced and to improve outcomes with little added risk.

O’Dell, Jr., R. H., MD; Sorgnard, R., PhD; May, H. U., MD. (2006). Electro analgesic Nerve Block, Practical Pain Management, April 2006.


Inflammation plays a key role in the perception of pain. Chronic inflammatory conditions are on the rise and there is controversy over whether the benefits of NSAIDs and steroids as anti-inflammatories outweigh the risks.

The principles of physics have been largely de-emphasized in modern medicine in favor of chemistry. However, electrotherapy, or Electronic Signal Treatment (EST) is a familiar application of physics that represents a powerful clinical tool which can improve overall patient care and maintenance of quality of life via low-risk and potentially curative treatments. EST should be reconsidered as an anti-inflammatory treatment that is safe, effective and long lasting.

EST, produced by advanced electronics not possible even 10 to 15 years ago, has widely accepted anti-inflammatory effects. Numerous citations exist in molecular biology, physics, and biochemical literature supporting these ideas. The beneficial actions include the oscillo/torsional effect, pH normalization, balancing metabolic concentration differences, cAMP formation and activation (leading to the normalization of cell function), cell membrane repair and stabilization, salutary effects on metabolism, sustained depolarization of the nerve cell membrane (producing nerve block), immune system support and the obvious macro benefits of increases in blood low and edema reduction.

O’Dell, R. H., MD, PhD and Sorgnard, R. E., PhD (2008). Anti-Inflammatory Effects of Electronic Signal Treatment, Pain Physician Journal, November/December 2008. 11:897-907, www.painphysicianjournal.com.


The principles of quantum theory (QT) claim that electrical currents and electromagnetic energy fields administered for pain treatment electronically induce and amplify subatomic particle movements and activity to create healing within cells. This study establishes that CET – Combined Electrochemical Treatment (which is based on the principles of the quantum theory) – is a more effective, safer treatment for DPN and other peripheral neuropathies than current pharmacologic regimens.

Study Details: from March 1, 2010, to February 28, 2013, 98 patients with various forms of PPN received a total of 107 series of CET treatments; The participants in the study were 50% women and 50% men, all average age 66 years. On a average, patients received 17.6 CET treatments. Patients rated their discomfort on a VAS score of 0-10 and their ability to function on a Peripheral Neuropathy Function Index (PNFI) score of 0-10

Study Results: CET was 54% to 62% more effective than pregabalin in reducing discomfort and improving function in patients with DPN and was associated with at least 95% fewer adverse events. When further studies confirm these results, GET must become the accepted standard of care for PPN

Carney, P., MD, PC (2014). Quantum Theory Treats Neuropathy Better Than Pharmacology, The Pain Practitioner, 24-4: 28-31. First presented the American Academy of Pain Management 2014 Clinical Meeting


Combining a local anesthetic with a unique current resulted in a significant decrease in pain associated with Diabetic Peripheral Neuropathy (DPN) 114 patients who had DPN-related pain were offered entry into this open label trial. 101 patients completed. The mean age of the study participant was 66.5 years. On a 10-point scale, patients that reported numbness reported an average per-treated pain score of 5.39. Post-treatment score was 0.98- an 81% reduction in symptoms. Patient’s without numbness saw a reduction rate of 87.2%. These subjective findings were supported by nerve conduction velocity testing. Patients with a mild DPN experienced more improvement. Overall this study indicates that using a combination of electric current and a nerve block to treat pain and numbness associated with DPN is effective and without effects.

Cernak, C., DPM, FACFAS, FACPPOPPM, FASPS; Marriott, E., MD; Martini, J., MD; Fleischmann, J., DPM, AACFAS; Silvani, B., R.NSC.T and McDermott, M.T. (2012). Electric Current & Local Anesthetic Combination Successfully Treats Pain Associated with Diabetic Neuropathy, Practical Pain Management, April 2012. Updated on May 1, 2012. Link: http://www.practicalpainmanage-ment.com/electric-current-local-anesthetic-combination-successfully-treats-pain-associated-diabetic


Available treatment options for Diabetic Peripheral Neuropathy (DPN) offer limited efficacy and potential side effects. Treatment results with Combination Electrochemical Therapy (CET) – Electronic Signal Treatment (EST) delivered with local anesthetic injections – show marked symptom and motor function improvement.

Study Details: 19 males and 13 females with a mean age of 69.4 years participated in an open-label trial that combined peripheral nerve injections using 0.25% Marcaine with EST. Patients received three treatments per week over a 4-week period. Study participants initially complained of sensory pain including numbness, tingling, RLS, and burning pain that limited daily activities.

Results: Pre- and post-treatment Nerve Conduction Velocity exams showed measurable objective improvement, findings which the authors believe offer substantive proof of the potential for this technology. CET seeks not only to relieve patient discomfort due to painful neuropathy, but also to help restore nerve function. Some patients showed recordable improvement in the amplitude of motor nerve conductions, indicating improvement of axonal nerve function. CET is safe, with risk limited due to the local anesthetic injections, with no risk from the electronic signals.

Cernak, C. DPM, FACFAS, FACPPOPPM, FASPS; O’Dell, Jr., R., MD; Marriott, E., MD, Silvani, B., R.NSC.T (2010). Combination Electrochemical Therapy (CET) to Treat Patients with Diabetic Neuropathy, Abstract submitted to 35th Annual Anesthesia Meetings and Workshops, April 2010.